Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population
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چکیده
منابع مشابه
association between methylenetetrahydrofolate reductase (mthfr) gene polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in an iranian population
background: the present study was aimed to examine the possible association between methylene tetrahydrofolate reductase (mthfr) gene polymorphisms and childhood acute lymphoblastic leukemia (all) in a sample of iranian population. subjects and methods: a total of 220 subjects including 100 children diagnosed with all and 120 healthy children participated in the case-control study. the single n...
متن کامل5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis.
There is evidence supporting a role for 5-10 methylenetetrahydrofolate reductase (MTHFR) gene variants in acute lymphoblastic leukemia (ALL). To provide a more robust estimate of the effect of MTHFR polymorphisms on the risk of ALL, we did a meta-analysis to reevaluate the association between the two most commonly studied MTHFR polymorphisms (C677T and A1298C) and ALL risk. All case-control stu...
متن کامل5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview.
Leukemias commonly arise as a result of DNA translocations, inversions, or deletions in genes regulating blood cell development or homeostasis. Folate deficiency has been associated with uracil misincorporation into DNA and DNA double strand breaks during uracil excision repair, thus increasing the risk of chromosomal aberrations. Methylenetetrahydrofolate reductase (MTHFR) directs 5,10-methyle...
متن کاملMethylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia.
Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers. Polymorphic variants of MTHFR lead to enhanced thymidine pools and better quality DNA synthesis that could afford some protection from the ...
متن کاملAssociation between Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphisms and Susceptibility to Childhood Acute Lymphoblastic Leukemia in an Iranian Population
BACKGROUND The present study was aimed to examine the possible association between methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms and childhood acute lymphoblastic leukemia (ALL) in a sample of Iranian population. SUBJECTS AND METHODS A total of 220 subjects including 100 children diagnosed with ALL and 120 healthy children participated in the case-control study. The single n...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2010
ISSN: 1347-9032,1349-7006
DOI: 10.1111/j.1349-7006.2009.01429.x